Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires

• Main Authors: Yi-Chun Hsiao (Author), Ying-Jiun J. Chen (Author), Leonard D. Goldstein (Author), Jia Wu (Author), Zhonghua Lin (Author), Kellen Schneider (Author), Subhra Chaudhuri (Author), Aju Antony (Author), Kanika Bajaj Pahuja (Author), Zora Modrusan (Author), Dhaya Seshasayee (Author), Somasekar Seshagiri (Author), Isidro Hötzel (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibodies from B-cell clonal lineages share sequence and structural properties as well as epitope specificity. Clonally unrelated antibodies can similarly share sequence and specificity properties and are said to be convergent. Convergent antibody responses against several antigens have been descri...