Pharmacokinetic Study of Praziquantel Enantiomers and Its Main Metabolite R-trans-4-OH-PZQ in Plasma, Blood and Dried Blood Spots in Opisthorchis viverrini-Infected Patients.

BACKGROUND:Praziquantel (PZQ) is the treatment of choice for infections with the liver fluke Opisthorchis viverrini, a major health problem in Southeast Asia. However, pharmacokinetic (PK) studies investigating the disposition of PZQ enantiomers (R- and S-PZQ) and its main metabolite, R-trans-4-OH-P...

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Main Authors: Isabel Meister (Author), Jana Kovac (Author), Urs Duthaler (Author), Peter Odermatt (Author), Jörg Huwyler (Author), Fiona Vanobberghen (Author), Somphou Sayasone (Author), Jennifer Keiser (Author)
Format: Book
Published: Public Library of Science (PLoS), 2016-05-01T00:00:00Z.
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