Performance of the SAEM and FOCEI Algorithms in the Open‐Source, Nonlinear Mixed Effect Modeling Tool nlmixr

• Main Authors: Rik Schoemaker (Author), Matthew Fidler (Author), Christian Laveille (Author), Justin J. Wilkins (Author), Richard Hooijmaijers (Author), Teun M. Post (Author), Mirjam N. Trame (Author), Yuan Xiong (Author), Wenping Wang (Author)
• Format: Book
• Published: Wiley, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The free and open‐source package nlmixr implements pharmacometric nonlinear mixed effects model parameter estimation in R. It provides a uniform language to define pharmacometric models using ordinary differential equations. Performances of the stochastic approximation expectation‐maximization (SAEM...