Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

• मुख्य लेखकों: Alexandre J. S. Ribeiro (लेखक), Brian D. Guth (लेखक), Michael Engwall (लेखक), Sandy Eldridge (लेखक), C. Michael Foley (लेखक), Liang Guo (लेखक), Gary Gintant (लेखक), John Koerner (लेखक), Stanley T. Parish (लेखक), Jennifer B. Pierson (लेखक), Mathew Brock (लेखक), Khuram W. Chaudhary (लेखक), Yasunari Kanda (लेखक), Brian Berridge (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human cardiomyocytes in vitro can provide mechanistic insight that can support the predict...