Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

• Main Authors: Alexandre J. S. Ribeiro (Author), Brian D. Guth (Author), Michael Engwall (Author), Sandy Eldridge (Author), C. Michael Foley (Author), Liang Guo (Author), Gary Gintant (Author), John Koerner (Author), Stanley T. Parish (Author), Jennifer B. Pierson (Author), Mathew Brock (Author), Khuram W. Chaudhary (Author), Yasunari Kanda (Author), Brian Berridge (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human cardiomyocytes in vitro can provide mechanistic insight that can support the predict...