Integrated Two‐Analyte Population Pharmacokinetic Model of Polatuzumab Vedotin in Patients With Non‐Hodgkin Lymphoma

• Main Authors: Dan Lu (Author), Tong Lu (Author), Leonid Gibiansky (Author), Xiaobin Li (Author), Chunze Li (Author), Priya Agarwal (Author), Colby S. Shemesh (Author), Rong Shi (Author), Randall C. Dere (Author), Jamie Hirata (Author), Dale Miles (Author), Pascal Chanu (Author), Sandhya Girish (Author), Jin Yan Jin (Author)
• Format: Book
• Published: Wiley, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A two‐analyte integrated population pharmacokinetic (PK) model that simultaneously describes concentrations of antibody‐conjugated monomethyl auristatin E (acMMAE) and unconjugated MMAE following repeated administrations of polatuzumab vedotin (pola) was developed based on data from four clinical st...