GSK3β Inhibition Prevents Macrophage Reprogramming by High-Dose Methotrexate

• Main Authors: Israel Ríos (Author), Baltasar López-Navarro (Author), Mónica Torres-Torresano (Author), Blanca Soler Palacios (Author), Miriam Simón-Fuentes (Author), Ángeles Domínguez-Soto (Author), Ittai B. Muller (Author), Gerrit Jansen (Author), Ángel L. Corbí (Author), Amaya Puig-Kröger (Author)
• Format: Book
• Published: Karger Publishers, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methotrexate (MTX) is an antifolate drug used as a chemotherapeutic agent for acute lymphoblastic leukemia, where MTX improves patients' prognosis. Macrophage reprogramming is being increasingly assessed as an antitumor therapeutic strategy. However, and although MTX limits the pathogenic actio...