Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance.

• Main Authors: Eugenia Lo (Author), Jessica B Hostetler (Author), Delenasaw Yewhalaw (Author), Richard D Pearson (Author), Muzamil M A Hamid (Author), Karthigayan Gunalan (Author), Daniel Kepple (Author), Anthony Ford (Author), Daniel A Janies (Author), Julian C Rayner (Author), Louis H Miller (Author), Guiyun Yan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the extent of PvDBP copy number variation, the type of PvDB...