Design, synthesis, molecular dynamics studies and biological evaluations of 4-hydroxy-5-pyrrolinone-3-carbohydrazides as HIV-1 integrase inhibitors

• Главные авторы: Nafiseh Karimi (Автор), Amirreza Dowlati Beirami (Автор), Rouhollah Vahabpour Roudsari (Автор), Zahra Hajimahdi (Автор), Afshin Zarghi (Автор)
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• Опубликовано: Elsevier, 2024-12-01T00:00:00Z.
• Предметы: article
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Acquired immune deficiency syndrome (AIDS) diseases despite the efficacy of anti-HIV therapy, remain one of the human's most serious problems. Hence, the introduction of novel anti-HIV agents as first-line therapy is still required. HIV integrase lacking human enzyme homologous is an interestin...