Design, synthesis, molecular dynamics studies and biological evaluations of 4-hydroxy-5-pyrrolinone-3-carbohydrazides as HIV-1 integrase inhibitors

• Principais autores: Nafiseh Karimi (Autor), Amirreza Dowlati Beirami (Autor), Rouhollah Vahabpour Roudsari (Autor), Zahra Hajimahdi (Autor), Afshin Zarghi (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2024-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Acquired immune deficiency syndrome (AIDS) diseases despite the efficacy of anti-HIV therapy, remain one of the human's most serious problems. Hence, the introduction of novel anti-HIV agents as first-line therapy is still required. HIV integrase lacking human enzyme homologous is an interestin...