Inhibition of sirtuin 2 with sulfobenzoic acid derivative AK1 is non-toxic and potentially neuroprotective in a mouse model of frontotemporal dementia

• Main Authors: Tara Leigh Spires-Jones (Author), Leora M Fox (Author), Anete eRozkalne (Author), Rose ePitstick (Author), George A Carlson (Author), Aleksey G. Kazantsev (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tauopathies including tau-associated Frontotemporal dementia and Alzheimer's disease are characterized pathologically by the formation of tau-containing neurofibrillary aggregates and neuronal loss, which contribute to cognitive decline. There are currently no effective treatments to prevent or...