Inhibition of sirtuin 2 with sulfobenzoic acid derivative AK1 is non-toxic and potentially neuroprotective in a mouse model of frontotemporal dementia

• Váldodahkkit: Tara Leigh Spires-Jones (Dahkki), Leora M Fox (Dahkki), Anete eRozkalne (Dahkki), Rose ePitstick (Dahkki), George A Carlson (Dahkki), Aleksey G. Kazantsev (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2012-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Tauopathies including tau-associated Frontotemporal dementia and Alzheimer's disease are characterized pathologically by the formation of tau-containing neurofibrillary aggregates and neuronal loss, which contribute to cognitive decline. There are currently no effective treatments to prevent or...