A Strategy for Selective Deletion of Autoimmunity-Related T Cells by pMHC-Targeted Delivery

• Main Authors: Shalom D. Goldberg (Author), Nathan Felix (Author), Michael McCauley (Author), Ryan Eberwine (Author), Lou Casta (Author), Kathleen Haskell (Author), Tricia Lin (Author), Elizabeth Palovick (Author), Donna Klein (Author), Lori Getts (Author), Robert Getts (Author), Mimi Zhou (Author), Pratima Bansal-Pakala (Author), Vadim Dudkin (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Autoimmune diseases such as rheumatoid arthritis are caused by immune system recognition of self-proteins and subsequent production of effector T cells that recognize and attack healthy tissue. Therapies for these diseases typically utilize broad immune suppression, which can be effective, but which...