Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase

• Main Authors: Yuanqing Gao (Author), Andrés Vidal-Itriago (Author), Irina Milanova (Author), Nikita L. Korpel (Author), Martin J. Kalsbeek (Author), Robby Zachariah Tom (Author), Andries Kalsbeek (Author), Susanna M. Hofmann (Author), Chun-Xia Yi (Author)
• Format: Book
• Published: Elsevier, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Leptin is a cytokine produced by adipose tissue that acts mainly on the hypothalamus to regulate appetite and energy homeostasis. Previous studies revealed that the leptin receptor is expressed not only in neurons, but also in glial cells. Microglia are resident immune cells in the brain...