CX-5461 is a potent immunosuppressant which inhibits T cell-mediated alloimmunity via p53-DUSP5

• Автори: Guopin Pan (Автор), Jing Zhang (Автор), Yu Han (Автор), Ye Chen (Автор), Xiaosun Guo (Автор), Xiaopei Cui (Автор), Mei Cheng (Автор), Haiqing Gao (Автор), Jianli Wang (Автор), Fan Jiang (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2022-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

CX-5461 is a first-in-class selective RNA polymerase I inhibitor. Previously we found that CX-5461 had anti-inflammatory activities. In this study we characterized potential immunosuppressive effects of CX-5461 and explored the underlying mechanisms. Allogeneic skin transplantation model (BALB/c to...