CX-5461 is a potent immunosuppressant which inhibits T cell-mediated alloimmunity via p53-DUSP5

• Main Authors: Guopin Pan (Author), Jing Zhang (Author), Yu Han (Author), Ye Chen (Author), Xiaosun Guo (Author), Xiaopei Cui (Author), Mei Cheng (Author), Haiqing Gao (Author), Jianli Wang (Author), Fan Jiang (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CX-5461 is a first-in-class selective RNA polymerase I inhibitor. Previously we found that CX-5461 had anti-inflammatory activities. In this study we characterized potential immunosuppressive effects of CX-5461 and explored the underlying mechanisms. Allogeneic skin transplantation model (BALB/c to...