CX-5461 is a potent immunosuppressant which inhibits T cell-mediated alloimmunity via p53-DUSP5

• প্রধান লেখক: Guopin Pan (লেখক), Jing Zhang (লেখক), Yu Han (লেখক), Ye Chen (লেখক), Xiaosun Guo (লেখক), Xiaopei Cui (লেখক), Mei Cheng (লেখক), Haiqing Gao (লেখক), Jianli Wang (লেখক), Fan Jiang (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2022-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

CX-5461 is a first-in-class selective RNA polymerase I inhibitor. Previously we found that CX-5461 had anti-inflammatory activities. In this study we characterized potential immunosuppressive effects of CX-5461 and explored the underlying mechanisms. Allogeneic skin transplantation model (BALB/c to...