CX-5461 is a potent immunosuppressant which inhibits T cell-mediated alloimmunity via p53-DUSP5

CX-5461 is a first-in-class selective RNA polymerase I inhibitor. Previously we found that CX-5461 had anti-inflammatory activities. In this study we characterized potential immunosuppressive effects of CX-5461 and explored the underlying mechanisms. Allogeneic skin transplantation model (BALB/c to...

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Main Authors: Guopin Pan (Author), Jing Zhang (Author), Yu Han (Author), Ye Chen (Author), Xiaosun Guo (Author), Xiaopei Cui (Author), Mei Cheng (Author), Haiqing Gao (Author), Jianli Wang (Author), Fan Jiang (Author)
Format: Book
Published: Elsevier, 2022-03-01T00:00:00Z.
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