Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine‐gingipain inhibitor COR388

• Auteurs principaux: Shirin Arastu‐Kapur (Auteur), Mai Nguyen (Auteur), Debasish Raha (Auteur), Florian Ermini (Auteur), Ursula Haditsch (Auteur), Joseph Araujo (Auteur), Ines A. M. De Lannoy (Auteur), Mark I. Ryder (Auteur), Stephen S. Dominy (Auteur), Casey Lynch (Auteur), Leslie J. Holsinger (Auteur)
• Format: Livre
• Publié: Wiley, 2020-02-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract COR388, a small‐molecule lysine‐gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease. Gingipains are produced by two species of bacteria, Porphyromonas gingivalis and Porphyromo...