Extracellular HMGB1 Induced Glomerular Endothelial Cell Injury via TLR4/MyD88 Signaling Pathway in Lupus Nephritis

• Main Authors: Tian Yu (Author), Feng Xiaojuan (Author), Liu Jinxi (Author), Miao Xinyan (Author), Xu Jie (Author), Tian Yuexin (Author), Liu Qingjuan (Author), Zhang Wei (Author), Gu Cunyang (Author), Huang Jie (Author), Wu Lunbi (Author), Zhao Hang (Author), Liu Shuxia (Author), Guo Huifang (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previously, our study showed that HMGB1 was significantly elevated in the blood and located in the glomerular endothelium in LN patients. But whether extracellular HMGB1 is involved in the injury of glomerular endothelial cells (GECs) in LN still needs further investigation. Firstly, we detected the...