Decoupling FcRn and tumor contributions to elevated immune checkpoint inhibitor clearance in cancer cachexia

• Main Authors: Trang T. Vu (Author), Kyeongmin Kim (Author), Millennium Manna (Author), Justin Thomas (Author), Bryan C. Remaily (Author), Emma J. Montgomery (Author), Travis Costa (Author), Lauren Granchie (Author), Zhiliang Xie (Author), Yizhen Guo (Author), Min Chen (Author), Alyssa Marie M. Castillo (Author), Samuel K. Kulp (Author), Xiaokui Mo (Author), Sridhar Nimmagadda (Author), Paul Gregorevic (Author), Dwight H. Owen (Author), Latha P. Ganesan (Author), Thomas A. Mace (Author), Christopher C. Coss (Author), Mitch A. Phelps (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients. Mechanisms linking ICI clearance, cachexia and ICI therapy failure are unknown. Here, we evaluate in four murine models and acro...