High-throughput screening for small molecule inhibitors of the type-I interferon signaling pathway

• Asıl Yazarlar: Elita Yuliantie (Yazar), Xinchuan Dai (Yazar), Dehua Yang (Yazar), Peter J. Crack (Yazar), Ming-Wei Wang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2018-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Interferons (IFNs) are cytokines with fundamental roles in resistance to infections, cancer and other diseases. Type-I IFNs, interferon α (IFN-α) and interferon β (IFN-β), act through a shared receptor complex (IFNAR) comprised of IFNAR1 and IFNAR2 subunits. Binding of type-I IFN to IFNAR1 will robu...