Monitoring Expression of Cytochrome P450 Genes During Postischemic Rat Liver Reperfusion Using DNA Microarrays
We investigated the expression of 50 cytochrome P450 (CYP) genes in the post-ischemic reperfused rat liver using a DNA microarray. Thirteen CYPs showed absent expression in all experiments and 2 CYPs were induced by pentobarbital, which was used as an anesthetic. Eight of the remaining 35 CYPs showe...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2005-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | We investigated the expression of 50 cytochrome P450 (CYP) genes in the post-ischemic reperfused rat liver using a DNA microarray. Thirteen CYPs showed absent expression in all experiments and 2 CYPs were induced by pentobarbital, which was used as an anesthetic. Eight of the remaining 35 CYPs showed significantly decreased expression following ischemia-reperfusion. Monitoring CYP expression may be a powerful approach for elucidation of pathways regulating drug metabolism that may be involved in postischemic reperfusion liver injury. Keywords:: cytochrome P450, postischemic liver reperfusion, gene expression |
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| Item Description: | 1347-8613 10.1254/jphs.rc0040040 |