Effects of Angiotensin Type I Receptor Blockade on the Cardiac Raf/MEK/ERK Cascade Activated via Adrenergic Receptors

• Main Authors: Guo-Xing Zhang (Author), Shoji Kimura (Author), Koji Murao (Author), Xiao Yu (Author), Koji Obata (Author), Hiroko Matsuyoshi (Author), Miyako Takaki (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A close interaction between adrenergic nerves and angiotensin systems has been documented. The present study was designed to investigate the mechanisms of angiotensin-receptor blocker (ARB) suppression of β-adrenergic receptor stimulation-induced cardiac hypertrophy. Chronic isoproterenol (ISO)-indu...