Peroxisome Proliferator-Activated Receptor-Gamma Reduces ER Stress and Inflammation via Targeting NGBR Expression

• Main Authors: Jialing Ma (Author), Peng Zeng (Author), Lipei Liu (Author), Mengmeng Zhu (Author), Juan Zheng (Author), Chengyi Wang (Author), Xiaokang Zhao (Author), Wenquan Hu (Author), Xiaoxiao Yang (Author), Yajun Duan (Author), Jihong Han (Author), Qing R. Miao (Author), Yuanli Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Increased Nogo-B receptor (NGBR) expression in the liver improves insulin sensitivity by reducing endoplasmic reticulum stress (ER stress) and activating the AMPK pathway, although it remains elusive the mechanisms by which NGBR is induced. In this study, we found that PPARγ ligands (rosiglitazone o...