Decreased plasma levels of PDGF-BB, VEGF-A, and HIF-2α in preterm infants after ibuprofen treatment

• Main Authors: Xuemei Huang (Author), Dongshan Han (Author), Yanfei Wei (Author), Bingchun Lin (Author), Dingyuan Zeng (Author), Yu Zhang (Author), Ba Wei (Author), Zhifeng Huang (Author), Xueyu Chen (Author), Chuanzhong Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionIbuprofen is one of the most common non-steroidal anti-inflammatory drugs used to close patent ductus arteriosus (PDA) in preterm infants. PDA is associated with bronchopulmonary dysplasia (BPD), while PDA closure by ibuprofen did not reduce the incidence of BPD or death. Previous studie...