Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice

• Main Authors: Patrick M. Schaefer (Author), Jessica Huang (Author), Arrienne Butic (Author), Caroline Perry (Author), Tal Yardeni (Author), Wendy Tan (Author), Ryan Morrow (Author), Joseph A. Baur (Author), Douglas C. Wallace (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Mitochondrial disorders are often characterized by muscle weakness and fatigue. Null mutations in the heart-muscle adenine nucleotide translocator isoform 1 (ANT1) of both humans and mice cause cardiomyopathy and myopathy associated with exercise intolerance and muscle weakness. Here we d...