Atorvastatin ascorbic acid cocrystal strategy to improve the safety and efficacy of atorvastatin

• Main Authors: Sunil Kumar Karumuri Taraka (Author), Praveen Kumar Pasala (Author), Ranjan Kumar Sahoo (Author), Umesh D. Laddha (Author), Shubham J. Khairnar (Author), Atul R. Bendale (Author), Mithun Rudrapal (Author)
• Format: Book
• Published: Pensoft Publishers, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The study was aimed to investigate the effect of dissolution enhancement on the hypolipidemic effect and hepatotoxicity of the drug in hyperlipidemic rats. Atorvastatin ascorbic acid cocrystals were prepared by phase solution methods and characterized by Fourier transformation infrared spectroscopy,...