Exploring Variability in Rifampicin Plasma Exposure and Development of Anti-Tuberculosis Drug-Induced Liver Injury among Patients with Pulmonary Tuberculosis from the Pharmacogenetic Perspective

• Main Authors: Agnija Kivrane (Author), Viktorija Ulanova (Author), Solveiga Grinberga (Author), Eduards Sevostjanovs (Author), Anda Viksna (Author), Iveta Ozere (Author), Ineta Bogdanova (Author), Maksims Zolovs (Author), Renate Ranka (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genetic polymorphisms can exert a considerable impact on drug pharmacokinetics (PK) and the development of adverse drug reactions (ADR). However, the effect of genetic polymorphisms on the anti-tuberculosis (anti-TB) drug, and particularly rifampicin (RIF), exposure or anti-TB drug-induced liver inj...