Mequindox-Induced Kidney Toxicity Is Associated With Oxidative Stress and Apoptosis in the Mouse

• Main Authors: Qianying Liu (Author), Zhixin Lei (Author), Jingchao Guo (Author), Aimei Liu (Author), Qirong Lu (Author), Zainab Fatima (Author), Haseeb Khaliq (Author), Muhammad A. B. Shabbir (Author), Muhammad Kashif Maan (Author), Qinghua Wu (Author), Menghong Dai (Author), Xu Wang (Author), Yuanhu Pan (Author), Zonghui Yuan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mequindox (MEQ), belonging to quinoxaline-di-N-oxides (QdNOs), is a synthetic antimicrobial agent widely used in China. Previous studies found that the kidney was one of the main toxic target organs of the QdNOs. However, the mechanisms underlying the kidney toxicity caused by QdNOs in vivo still re...