Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

Objective: Transport of Ca2+ into pancreatic β cell mitochondria facilitates nutrient-mediated insulin secretion. However, the underlying mechanism is unclear. Recent establishment of the molecular identity of the mitochondrial Ca2+ uniporter (MCU) and associated proteins allows modification of mito...

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Main Authors: N. Vishnu (Author), A. Hamilton (Author), A. Bagge (Author), A. Wernersson (Author), E. Cowan (Author), H. Barnard (Author), Y. Sancak (Author), K.J. Kamer (Author), P. Spégel (Author), M. Fex (Author), A. Tengholm (Author), V.K. Mootha (Author), D.G. Nicholls (Author), H. Mulder (Author)
Format: Book
Published: Elsevier, 2021-09-01T00:00:00Z.
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