Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis Induction

• Main Authors: Bárbara Pinto (Author), João P. N. Silva (Author), Patrícia M. A. Silva (Author), Daniel José Barbosa (Author), Bruno Sarmento (Author), Juliana Carvalho Tavares (Author), Hassan Bousbaa (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antimitotic compounds, targeting key spindle assembly checkpoint (SAC) components (e.g., MPS1, Aurora kinase B, PLK1, KLP1, CENPE), are potential alternatives to microtubule-targeting antimitotic agents (e.g., paclitaxel) to circumvent resistance and side effects associated with their use. They can...