HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo

• Main Authors: Burcin Gungor (Author), Lauri Vanharanta (Author), Maarit Hölttä-Vuori (Author), Juho Pirhonen (Author), Nikolaj H.T. Petersen (Author), Silvia Gramolelli (Author), Päivi M. Ojala (Author), Thomas Kirkegaard (Author), Elina Ikonen (Author)
• Format: Book
• Published: Elsevier, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Heat Shock Proteins (HSPs) maintain cellular homeostasis under stress. HSP70 represents a major stress-inducible family member and has been identified as a druggable target in inherited cholesterol-sphingolipid storage diseases. We investigated if HSP70 modulates cholesterol accumulation...