HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo

• Główni autorzy: Burcin Gungor (Autor), Lauri Vanharanta (Autor), Maarit Hölttä-Vuori (Autor), Juho Pirhonen (Autor), Nikolaj H.T. Petersen (Autor), Silvia Gramolelli (Autor), Päivi M. Ojala (Autor), Thomas Kirkegaard (Autor), Elina Ikonen (Autor)
• Format: Książka
• Wydane: Elsevier, 2019-10-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Objective: Heat Shock Proteins (HSPs) maintain cellular homeostasis under stress. HSP70 represents a major stress-inducible family member and has been identified as a druggable target in inherited cholesterol-sphingolipid storage diseases. We investigated if HSP70 modulates cholesterol accumulation...