Inclisiran: a new generation of lipid-lowering siRNA therapeutic

• Main Authors: Yanzhen Zhang (Author), Huaigang Chen (Author), Lang Hong (Author), Hong Wang (Author), Bin Li (Author), Mengyin Zhang (Author), Jiamei Li (Author), Liu Yang (Author), Fan Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Atherosclerotic heart disease (AHD) is a major cause of morbidity and mortality worldwide. Lowering low-density lipoprotein cholesterol (LDL-C) levels is a key strategy to prevent and treat AHD. Inclisiran is a novel siRNA drug that targets proprotein convertase subtilisin/kexin type 9 (PCSK9) gene...