Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo

• Główni autorzy: Xiaosen Ouyang (Autor), Willayat Y. Wani (Autor), Gloria A. Benavides (Autor), Matthew J. Redmann (Autor), Hai Vo (Autor), Thomas van Groen (Autor), Victor M. Darley-Usmar (Autor), Jianhua Zhang (Autor)
• Format: Książka
• Wydane: Elsevier, 2023-10-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The lysosome is responsible for protein and organelle degradation and homeostasis and the cathepsins play a key role in maintaining protein quality control. Cathepsin D (CTSD), is one such lysosomal protease, which when deficient in humans lead to neurolipofuscinosis (NCL) and is important in removi...