Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo

• Main Authors: Xiaosen Ouyang (Author), Willayat Y. Wani (Author), Gloria A. Benavides (Author), Matthew J. Redmann (Author), Hai Vo (Author), Thomas van Groen (Author), Victor M. Darley-Usmar (Author), Jianhua Zhang (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The lysosome is responsible for protein and organelle degradation and homeostasis and the cathepsins play a key role in maintaining protein quality control. Cathepsin D (CTSD), is one such lysosomal protease, which when deficient in humans lead to neurolipofuscinosis (NCL) and is important in removi...