Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana.

• Main Authors: Edith A Fernández-Figueroa (Author), Iván Imaz-Rosshandler (Author), Juan E Castillo-Fernández (Author), Haydee Miranda-Ortíz (Author), Juan C Fernández-López (Author), Ingeborg Becker (Author), Claudia Rangel-Escareño (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An important NK-cell inhibition with reduced TNF-α, IFN-γ and TLR2 expression had previously been identified in patients with diffuse cutaneous leishmaniasis (DCL) infected with Leishmania mexicana. In an attempt to pinpoint alterations in the signaling pathways responsible for the NK-cell dysfuncti...