Discovery of potent and noncovalent KRASG12D inhibitors: Structure-based virtual screening and biological evaluation

• Main Authors: Yuting Wang (Author), Hai Zhang (Author), Jindong Li (Author), Miao-Miao Niu (Author), Yang Zhou (Author), Yuanqian Qu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

KRASG12D, the most common oncogenic KRAS mutation, is a promising target for the treatment of pancreatic cancer. Herein, we identified four potent and noncovalent KRASG12D inhibitors (hits 1-4) by using structure-based virtual screening and biological evaluation. The in vitro assays indicated that t...