Regulation and Prognostic Relevance of Symmetric Dimethylarginine Serum Concentrations in Critical Illness and Sepsis

• Main Authors: Alexander Koch (Author), Ralf Weiskirchen (Author), Jan Bruensing (Author), Hanna Dückers (Author), Lukas Buendgens (Author), Julian Kunze (Author), Michael Matthes (Author), Tom Luedde (Author), Christian Trautwein (Author), Frank Tacke (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In systemic inflammation and sepsis, endothelial activation and microvascular dysfunction are characteristic features that promote multiorgan failure. As symmetric dimethylarginine (SDMA) impacts vascular tension and integrity via modulating nitric oxide (NO) pathways, we investigated circulating SD...