Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice

• Main Authors: María González-Núñez (Author), Adela S. Riolobos (Author), Orlando Castellano (Author), Isabel Fuentes-Calvo (Author), María de los Ángeles Sevilla (Author), Bárbara Oujo (Author), Miguel Pericacho (Author), Ignacio Cruz-Gonzalez (Author), Fernando Pérez-Barriocanal (Author), Peter ten Dijke (Author), Jose M. López-Novoa (Author)
• Format: Book
• Published: The Company of Biologists, 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The activin receptor-like kinase 1 (ALK-1) is a type I cell-surface receptor for the transforming growth factor-β (TGF-β) family of proteins. Hypertension is related to TGF-β1, because increased TGF-β1 expression is correlated with an elevation in arterial pressure (AP) and TGF-β expression is upreg...