Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats

Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats

Ovarian damage and fertility impairment are major side effects of chemotherapy in pre-menopausal cancer patients. Cisplatin is a widely used chemotherapeutic drug. The present study was designed to assess the ameliorative effects of melatonin as an adjuvant for fertility preservation. Thirty-two adu...

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Main Authors: Amal Al-Shahat (Author), Mohey A. E. Hulail (Author), Nada M. M. Soliman (Author), Tarek Khamis (Author), Liana Mihaela Fericean (Author), Ahmed Hamed Arisha (Author), Rania S. Moawad (Author)
Format: Book
Published: MDPI AG, 2022-12-01T00:00:00Z.
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