Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats

• Главные авторы: Amal Al-Shahat (Автор), Mohey A. E. Hulail (Автор), Nada M. M. Soliman (Автор), Tarek Khamis (Автор), Liana Mihaela Fericean (Автор), Ahmed Hamed Arisha (Автор), Rania S. Moawad (Автор)
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• Опубликовано: MDPI AG, 2022-12-01T00:00:00Z.
• Предметы: article
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Ovarian damage and fertility impairment are major side effects of chemotherapy in pre-menopausal cancer patients. Cisplatin is a widely used chemotherapeutic drug. The present study was designed to assess the ameliorative effects of melatonin as an adjuvant for fertility preservation. Thirty-two adu...