Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats

• Autores principales: Amal Al-Shahat (Autor), Mohey A. E. Hulail (Autor), Nada M. M. Soliman (Autor), Tarek Khamis (Autor), Liana Mihaela Fericean (Autor), Ahmed Hamed Arisha (Autor), Rania S. Moawad (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2022-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Ovarian damage and fertility impairment are major side effects of chemotherapy in pre-menopausal cancer patients. Cisplatin is a widely used chemotherapeutic drug. The present study was designed to assess the ameliorative effects of melatonin as an adjuvant for fertility preservation. Thirty-two adu...