Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats

• Auteurs principaux: Amal Al-Shahat (Auteur), Mohey A. E. Hulail (Auteur), Nada M. M. Soliman (Auteur), Tarek Khamis (Auteur), Liana Mihaela Fericean (Auteur), Ahmed Hamed Arisha (Auteur), Rania S. Moawad (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Ovarian damage and fertility impairment are major side effects of chemotherapy in pre-menopausal cancer patients. Cisplatin is a widely used chemotherapeutic drug. The present study was designed to assess the ameliorative effects of melatonin as an adjuvant for fertility preservation. Thirty-two adu...