Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats

• Päätekijät: Amal Al-Shahat (Tekijä), Mohey A. E. Hulail (Tekijä), Nada M. M. Soliman (Tekijä), Tarek Khamis (Tekijä), Liana Mihaela Fericean (Tekijä), Ahmed Hamed Arisha (Tekijä), Rania S. Moawad (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Ovarian damage and fertility impairment are major side effects of chemotherapy in pre-menopausal cancer patients. Cisplatin is a widely used chemotherapeutic drug. The present study was designed to assess the ameliorative effects of melatonin as an adjuvant for fertility preservation. Thirty-two adu...