A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome

• Main Authors: Miriam Kron (Author), Min Lang (Author), Ian T. Adams (Author), Michael Sceniak (Author), Frank Longo (Author), David M. Katz (Author)
• Format: Book
• Published: The Company of Biologists, 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reduced levels of brain-derived neurotrophic factor (BDNF) are thought to contribute to the pathophysiology of Rett syndrome (RTT), a severe neurodevelopmental disorder caused by loss-of-function mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2). In Mecp2 mutant mice, BDNF deficits...