Novel sulphonamide-bearing methoxyquinazolinone derivatives as anticancer and apoptosis inducers: synthesis, biological evaluation and in silico studies

We synthesised a new series of sulphonamide-bearing quinazolinone derivatives 5-18 and evaluated their in vitro cytotoxicity in various cancer cell lines (A549, HepG-2, LoVo and MCF-7) and in normal human cells (HUVEC). Compounds 6 and 10 exhibited the higher activity against all the cancer cell lin...

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Main Authors: Ali S. Alqahtani (Author), Mostafa M. Ghorab (Author), Fahd A. Nasr (Author), Mohammad Z. Ahmed (Author), Abdullah A. Al-Mishari (Author), Sabry M. Attia (Author)
Format: Book
Published: Taylor & Francis Group, 2022-01-01T00:00:00Z.
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