AKR1C3 in carcinomas: from multifaceted roles to therapeutic strategies

• Main Authors: Mengnan Li (Author), Limin Zhang (Author), Jiahui Yu (Author), Xiaoxiao Wang (Author), Le Cheng (Author), Zhaowu Ma (Author), Xiaoguang Chen (Author), Lingzhi Wang (Author), Boon Cher Goh (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aldo-Keto Reductase Family 1 Member C3 (AKR1C3), also known as type 5 17β-hydroxysteroid dehydrogenase (17β-HSD5) or prostaglandin F (PGF) synthase, functions as a pivotal enzyme in androgen biosynthesis. It catalyzes the conversion of weak androgens, estrone (a weak estrogen), and PGD2 into potent...