Effects of Deacetylase Inhibition on the Activation of the Antioxidant Response and Aerobic Metabolism in Cellular Models of Fanconi Anemia

• Main Authors: Nadia Bertola (Author), Stefano Regis (Author), Silvia Bruno (Author), Andrea Nicola Mazzarello (Author), Martina Serra (Author), Michela Lupia (Author), Federica Sabatini (Author), Fabio Corsolini (Author), Silvia Ravera (Author), Enrico Cappelli (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fanconi anemia (FA) is a rare genetic disease characterized by a dysfunctional DNA repair and an oxidative stress accumulation due to defective mitochondrial energy metabolism, not counteracted by endogenous antioxidant defenses, which appear down-expressed compared to the control. Since the antioxi...