The Effects of CYP2C19 Genotype on Proxies of SSRI Antidepressant Response in the UK Biobank

• Main Authors: Win Lee Edwin Wong (Author), Chiara Fabbri (Author), Benjamin Laplace (Author), Danyang Li (Author), Roos van Westrhenen (Author), Cathryn M. Lewis (Author), Gavin Stewart Dawe (Author), Allan H. Young (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used psychopharmaceutical treatment for major depressive disorder (MDD), but individual responses to SSRIs vary greatly. CYP2C19 is a key enzyme involved in the metabolism of several drugs, including SSRIs. Variations in the CYP2C...