Phenotype-driven gene prioritization for rare diseases using graph convolution on heterogeneous networks

• Main Authors: Aditya Rao (Author), Saipradeep VG (Author), Thomas Joseph (Author), Sujatha Kotte (Author), Naveen Sivadasan (Author), Rajgopal Srinivasan (Author)
• Format: Book
• Published: BMC, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background One of the major goals of genomic medicine is the identification of causal genomic variants in a patient and their relation to the observed clinical phenotypes. Prioritizing the genomic variants by considering only the genotype information usually identifies a few hundred potenti...