Viral delivery of a peptide-based immunomodulator enhances T cell priming during vaccination

• Main Authors: Timothy W. Phares (Author), Jing Huang (Author), Vinayaka Kotraiah (Author), Mary J. Hauser (Author), Arban Domi (Author), Sreenivasa Oruganti (Author), Cecille D. Browne (Author), Peter Buontempo (Author), Marc Mansour (Author), James Pannucci (Author), Moriya Tsuji (Author), Gabriel M. Gutierrez (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Modern, subunit-based vaccines have so far failed to induce significant T cell responses, contributing to ineffective vaccination against many pathogens. Importantly, while today's adjuvants are designed to trigger innate and non-specific immune responses, they fail to directly stimulate the ad...