Transgenic mice Cre-dependently expressing mutant polymerase-gamma: novel test-system for pharmacological study of mitoprotective drugs

• Main Authors: Marina V. Kubekina (Author), Yulia Yu. Silaeva (Author), Alexandra V. Bruter (Author), Diana S. Korshunova (Author), Leonid A. Ilchuk (Author), Yulia D. Okulova (Author), Mariya O. Soldatova (Author), Evgeniya Seryogina (Author), Inga M. Kolesnik (Author), Polina A. Ukolova (Author), Mikhail V. Korokin (Author), Alexey V. Deykin (Author)
• Format: Book
• Published: Belgorod National Research University, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: PolG-alpha is a nuclear-encoded enzyme which provides replication and repair of mitochondrial DNA. D257A mutation of PolG-alpha leads to change in the N-terminal "proofreading" domain, which deprives the enzyme of 3'-5' exonuclease activity, resulting in accumulatio...