Transgenic mice Cre-dependently expressing mutant polymerase-gamma: novel test-system for pharmacological study of mitoprotective drugs

• Principais autores: Marina V. Kubekina (Autor), Yulia Yu. Silaeva (Autor), Alexandra V. Bruter (Autor), Diana S. Korshunova (Autor), Leonid A. Ilchuk (Autor), Yulia D. Okulova (Autor), Mariya O. Soldatova (Autor), Evgeniya Seryogina (Autor), Inga M. Kolesnik (Autor), Polina A. Ukolova (Autor), Mikhail V. Korokin (Autor), Alexey V. Deykin (Autor)
• Formato: Livro
• Publicado em: Belgorod National Research University, 2021-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Introduction: PolG-alpha is a nuclear-encoded enzyme which provides replication and repair of mitochondrial DNA. D257A mutation of PolG-alpha leads to change in the N-terminal "proofreading" domain, which deprives the enzyme of 3'-5' exonuclease activity, resulting in accumulatio...