IDH Mutation Analysis in Ewing Sarcoma Family Tumors

• Main Authors: Ki Yong Na (Author), Byeong-Joo Noh (Author), Ji-Youn Sung (Author), Youn Wha Kim (Author), Eduardo Santini Araujo (Author), Yong-Koo Park (Author)
• Format: Book
• Published: Korean Society of Pathologists & the Korean Society for Cytopathology, 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to yield α-ketoglutarate (α-KG) with production of reduced nicotinamide adenine dinucleotide (NADH). Dysfunctional IDH leads to reduced production of α-KG and NADH and increased production of 2-hydroxygl...