Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice

• Egile Nagusiak: Zhenlei Zhao (Egilea), Fan Xue (Egilea), Yanpei Gu (Egilea), Jianxin Han (Egilea), Yingxian Jia (Egilea), Keqiang Ye (Egilea), Ying Zhang (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2021-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Objective: 7,8-Dihydroxyflavone (7,8-DHF), a small molecular mimetic of brain-derived neurotrophic factor (BDNF), alleviates high-fat diet-induced obesity in female mice in a sex-specific manner by activating muscular tropomyosin-related kinase B (TrkB). However, the underlying molecular mechanism f...