Gut microbiota and metabolites signatures of clinical response in anti-PD-1/PD-L1 based immunotherapy of biliary tract cancer

• Main Authors: Chengpei Zhu (Author), Yunchao Wang (Author), Ruijuan Zhu (Author), Shanshan Wang (Author), Jingnan Xue (Author), Dongya Zhang (Author), Zhou Lan (Author), Chenchen Zhang (Author), Yajun Liang (Author), Nan Zhang (Author), Ziyu Xun (Author), Longhao Zhang (Author), Cong Ning (Author), Xu Yang (Author), Jiashuo Chao (Author), Junyu Long (Author), Xiaobo Yang (Author), Hanping Wang (Author), Xinting Sang (Author), Xianzhi Jiang (Author), Haitao Zhao (Author)
• Format: Bog
• Udgivet: BMC, 2024-06-01T00:00:00Z.
• Fag: article
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Abstract Background Accumulating evidence suggests that the gut microbiota and metabolites can modulate tumor responses to immunotherapy; however, limited data has been reported on biliary tract cancer (BTC). This study used metagenomics and metabolomics to identify characteristics of the gut microb...