A Buried Water Network Modulates the Activity of the <i>Escherichia coli</i> Disulphide Catalyst DsbA

• Main Authors: Geqing Wang (Author), Jilong Qin (Author), Anthony D. Verderosa (Author), Lilian Hor (Author), Carlos Santos-Martin (Author), Jason J. Paxman (Author), Jennifer L. Martin (Author), Makrina Totsika (Author), Begoña Heras (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The formation of disulphide bonds is an essential step in the folding of many proteins that enter the secretory pathway; therefore, it is not surprising that eukaryotic and prokaryotic organisms have dedicated enzymatic systems to catalyse this process. In bacteria, one such enzyme is disulphide bon...