Proposal of Potent Inhibitors for a Bacterial Cell Division Protein FtsZ: Molecular Simulations Based on Molecular Docking and ab Initio Molecular Orbital Calculations

• Main Authors: Shohei Yamamoto (Author), Ryosuke Saito (Author), Shunya Nakamura (Author), Haruki Sogawa (Author), Pavel Karpov (Author), Sergey Shulga (Author), Yaroslav Blume (Author), Noriyuki Kurita (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The inhibition of a bacterial cell division protein, filamentous temperature-sensitive Z (FtsZ), prevents the reproduction of <i>Mycobacteria</i>. To propose potent inhibitors of FtsZ, the binding properties of FtsZ with various derivatives of Zantrin ZZ3 were investigated at an electron...