Effects of Antiarrhythmic Drugs on hERG Gating in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1

• Main Authors: Mengying Huang (Author), Zhenxing Liao (Author), Xin Li (Author), Zhen Yang (Author), Xuehui Fan (Author), Yingrui Li (Author), Zhihan Zhao (Author), Siegfried Lang (Author), Lukas Cyganek (Author), Xiaobo Zhou (Author), Ibrahim Akin (Author), Martin Borggrefe (Author), Ibrahim El-Battrawy (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: The short QT syndrome type 1 (SQT1) is linked to hERG channel mutations (e.g., N588K). Drug effects on hERG channel gating kinetics in SQT1-cells have not been investigated.Methods: This study used hiPSC-CMs of a healthy donor and a SQT1-patient carrying the N588K mutation and patch clamp to e...